35 Moreover, druggability is another important prioritization criterion for therapeutic targets; that is defined as the likelihood of being able to modulate the activity of the therapeutic target protein with a small-molecule drug.
Additionally, as OVA can be used to prioritize genes as well as variants, we have opted to compare our approach with another gene prioritization tool, G2D (Perez-Iratxeta et al., 2007).
This value was arrived at during optimization for another exome prioritization tool (Robinson et al., 2014) and represents a compromise between assuming novel variants are non-pathogenic or fully pathogenic.
One man's prioritization is another man's discrimination.
Likewise, Strategy 3 places the failure in the middle of the sequence – another case that a prioritization technique must avoid.
Finally, we show that our tool compares favorably to another recently published variant prioritization tool, ExomeWalker (Smedley et al., 2014).
We show that our model distinguishes relevant genes accurately and, coupled with our variant filtering approach, performs better than another recently published variant prioritization tool (Fig. 3).
Another important step in the prioritization of values is the establishment of flood risk management plans (step 3).
Nor do they permit the prioritization of one viewpoint over another or one news outlet over another".
