For this reason, we performed the landmark finding on high-resolutions images, thus given them an advantage over SHR.
This landmark finding strongly suggests that the overlapping phenotypical and clinical presentation of mutations is directly linked to a common cellular function of the affected gene products within the cell.
Another excellent possibility for how the gap between the Uba2 and Ubc9 catalytic cysteines could be closed comes from the recent landmark finding that the Uba2 catalytic cysteine domain can undergo dramatic reorientation and remodeling [20].
The identification of NOD2 as the first CD susceptibility gene in 2001 represents a landmark finding that implicated bacterial recognition and innate immunity as key processes involved in the pathogenesis of CD.
Demonstrating that the changes in spindle size during early development are driven by the changing biochemistry of the cytoplasm is a landmark finding that pushes the field forward and allows new, more precise questions to be formulated.
Both methods, however, need a good initialization to find an accurate registration, which can be provided by, for instance, the Viola and Jones landmark finding method.
That landmark finding, firmly established by dozens of observational studies and three randomized controlled trials in South Africa, Uganda and Kenya, has made male circumcision the most promising method of prevention in the anti-AIDS arsenal.
One landmark finding that emerged from the wealth of recent sequencing data was the identification of the highly recurrent heterozygous Y641 mutation (Y/F, Y/N, Y/H, Y/C) in FL, DLBCL, and other lymphoid neoplasms (Bodor et al., 2013; Bodor et al., 2011; Morin et al., 2010).
In a landmark finding by Thomas Langer's group, the authors identified proteins that interact with the m-AAA complex [ 74].
A landmark finding was that a conserved cysteine in RING2 forms a transient thioester bond with ubiquitin, facilitating subsequent ubiquitin ligation to a lysine (Wenzel et al, 2011).
