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To define sequences homologous to lobe B, the sequences of lobe B that are defined structurally in the PDB (from protein 4.1R, merlin, ezrin, radxin, moesin, talin) were used to make another HMM specific for lobe B. Searching Uniprot with this HMM defined lobe B in the majority of known members of the superfamily.
In theory, this new canonical model can be used to re-estimate the optimal warp factors, and another HMM can be trained and the procedure iterated several times.
The probability of the sequences being neither an ncRNA nor a protein coding RNA is calculated by another HMM which considers mutations that take place independent of position.
To account for rate heterogeneity, we allow this parameter to vary along the alignment using another HMM.
In parallel, another HMM profile was computed for the closest homologous sequences present in the seed alignment (HMM_seed).
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Birdseye, another HMM-based approach, was developed to detect CNVs in SNP genotyping arrays specifically for Affymetrix platforms [16].
Another intent "Hmm," and then another question.
"You want another grape, hmm?" Mr. Kilham asked gently.
Another popular HMM platform is SAM Barrettt et al., 1997; Hughey and Krogh 1996; Karplus et al., 2005), which is used by SUPERFAMILY We used HMMER rather than SAM for all our HMM-based queries because the programs' retrieval performances were shown to be comparable (Madera and Gough 2002; Wistrand and Sonnhammer 2005) and because the SUPERFAMILY models were available in HMMER format.
"My first thought was 'Not another Agatha Christie!'" Hmm.
Maersk's main rival in the acquisition is Hyundai Merchant Marine (HMM), another Korean shipper.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com