Exact(4)
Jayant projects another gain of 1 million subscribers for EchoStar in 2003.
This resulted in another gain of 4.8% of the available sample size.
The transition-based model of Engelhardt et al. assumes replacement of one function by another (gain of one function coupled to the loss of another), and does not capture uncoupled events, which is particularly important for BP annotations and cases where a protein has multiple molecular functions (see examples below).
Another gain of linked genes occurred in a direct ancestor of Listeria sensu strictu, resulting in the formation of the propane-2-diol/ethanolamine/cobalamin locus, at least parts of which have been shown to be essential for pathogenesis of L. monocytogenes (Mellin et al. 2014) and other bacteria (Conner et al. 1998; Joseph et al. 2006; Klumpp and Fuchs 2007; Srikumar and Fuchs 2010).
Similar(56)
We decided to extend observations to another gain-of-function model produced in our laboratory that, differently from the HGF tg mouse, allows activation of Met in the absence of the ligand and cannot be downregulated [22].
We had another net gain of 359,000 in domestic migration and 58,000 in international migration from 1990 to 1998.
Another example of gain-of-function in p300/CBP is in viral transformation.
KIT, another RTK, undergoes gain-of-function mutation in >90% of gastrointestinal stromal tumours (GISTs) leading to the activation of PI3K-AKT, mitogen-activated protein kinase (MAPK), STAT-1 and STAT-3 prosurvival pathways (Duensing et al, 2004).
120, 121 Another hypothesis assumes a gain-of-function through alteration of the protein structure.
JAK2 fusion proteins, such as TEL-JAK2 detected in T- and B-ALL and BCR-ABL-negative chronic myeloid leukemia (CML), are another class of oncogenic gain-of-function JAK2 mutants (Van Roosbroeck et al., 2011).
The paper is another example of so-called gain-of-function studies, a controversial field in which researchers deliberately manipulate viruses in ways that can make them more dangerous.
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