In reality, difficulty exists when directly applying the original WFs in the GNSS system.
However, difficulty exists in doing this, which comes from the fact that the failure of the utmost filament of the composite archwire subjected to initially the maximum bending stress does not imply its ultimate failure.
As a consequence, difficulty exists in comparing results, precluding meta-analysis [ 30].
However, difficulty exists in distinguishing between invasive tumour and benign adhesions.
For example, difficulty exists when no remaining tumours can be identified on macroscopic examination.
10 12 Although difficulty exists in attributing causation with regard to falling and LOS, it is likely that capacity exists to reduce LOS through preventing falls events in hospital.
However, this difficulty exists worldwide, and it might be alleviated by in vitro reconstitution [ 17] and modified enzymes used in the fatty acid biosynthesis pathway through rational protein design, as well as improved fatty acyl-CoAs supply.
In addition, just as comigration of proteins upon the 2D-gel can cause quantitation problems, a similar difficulty exists with MS-based quantitation due to overlapping signals from different ion species unless high-resolution MS is used [ 102, 133].
A particular difficulty exists for populations which have reduced LD due to extended population history, such as those from Sub-Saharan Africa, for which considerably higher marker coverage is required for complete coverage.
Difficulty exists in determining which measures used in the stroke SMIs in this review reflect self-management with validity since most measures did not score well according to the COSMIN criteria.
