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Anomalous expression of miRNAs has been linked with cell cycles such as cell proliferation, stress response, differentiation, cell apoptosis and inflammation, which present a manifestation of multitude types of disorders and malignancies.
The anomalous expression of integrin beta 1 and keratinocyte differentiation marker K6 suggests that loss of selenoproteins in skin contributes to psoriasis like conditions in the knockout progeny.
The livers of UN animals show changes in the anomalous expression of RNA for several enzymes involved in glycogenesis, glycogenolysis and glycolysis.
A mixture model identified the putative supt5h protein (44.m02759, TGME49_033000) and the DNA primase (113.m00800, TGME49_097840) genes as having highly anomalous expression in the mutants and, thus, may be involved in the switching mechanism.
ANXA1 appearance is in a tissue- and tumour-specific manner and its anomalous expression is closely related to cancer progression [ 8, 9].
DUX4 encodes a transcription factor that is believed to be involved in myogenic differentiation, and its anomalous expression in adult muscle in FSHD provides an attractive target for knockdown or inhibitory therapies.
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Anomalous expressions of plasminogen activator system proteins as well as various matrix metalloproteinases (MMPs) seem to be responsible for this phenomenon [ 22].
Based on the anomalous differential expression of the certain cell surface proteins, the patients were classified broadly into three groups, OAcSGP+CD10+CD19+ or OAcSGP+CD34+CD19+ for B-ALL and OAcSGP+CD7+CD3+ for T-ALL.
The results of this study indicate an anomalous pattern of expression of Rb in classical forms of Hodgkin's disease, and suggest the possibility of undertaking functional studies (E1A adhesion, p16 expression) with the aim of better characterising the status of Rb protein, and correlating these findings with clinical course in Hodgkin's disease patients.
Chronic immune activation and anomalous miRNA expression have been regarded as important players in the pathological molecular mechanisms underlying cardiac disease.
The onset of infection and subsequent occurrence of sepsis is linked with anomalous gene expression of γc cytokines IL-2 and IL-7.
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CEO of Professional Science Editing for Scientists @ prosciediting.com