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We demonstrated that annotations of experiments may be leveraged to enrich a user's data exploration experience.
Nonetheless, tools such as AnnotCompute may provide an incentive for richer annotations of experiments.
We enriched the annotations of experiments in the result set consistently, irrespective of whether they were used as a query experiment and of their rank.
We observe that ArrayExpress already includes information that may facilitate such grouping, namely, the annotations of experiments with terms from the MGED Ontology (MO) (2) and, more recently, the Experimental Factor Ontology (EFO) (3) and Ontology for Biomedical Investigations (OBI) (4) ontologies.
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Annotation of experiments is assisted by an integrated ontology lookup service.
Developed by harnessing the Google Spreadsheet environment and the term lookup and annotation power of the NCBO Web services, OntoMaton is an effective tool assisting both collaborative semantic annotation of experiments and the ontology development process.
The quantified data files were transferred to a GeneTraffic microarray database and analysis system (Iobion Informatics, Stratagene) with a complete annotation of experiments based on the current MIAME standards for microarray experiments.
We hope that the adoption of AnnotCompute and of other meta-analysis tools by the scientific community will serve as an in incentive for more judicious annotation of experiments.
In contrast to other solutions that put the focus on management of thousands of samples for core sequencing facilities, the STATegra EMS has as primary goal the annotation of experiments designed and run at individual research laboratories.
Our approach is similar in spirit, but leverages the already standardized annotations of ArrayExpress experiments with ontology terms that were developed specifically to annotate functional genomics experiments (like the MGED Ontology).
Annotations of 10 639 experiments (87%) were extracted successfully.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com