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Among the annotated contigs, 23 that had an annotation related to peptide phosphorylation had an expression level higher than in the resistant pool.
For these experiments, we selected 15 genes with a functional annotation related to skin homeostasis that had shown different degrees of age-related downregulation in our RNA-seq analysis.
Consistent with this, the differentially expressed collection from both memory and Treg cells was significantly enriched for genes with gene ontology (GO) term annotation related to lymphocyte activation (Table S2).
Approximately 300 sequenced genomes from environmental bacteria and archaea (251 and 48, respectively) were used for keyword-based selection of genes from those genomes with well-defined functional annotation related to carbon and nitrogen metabolism (which made up 48% and 27% of the selected genes, respectively).
Functional annotation related to the transcriptome was obtained using the BLAST2GO package [ 72].
The database contains every structural and functional annotation related to the unigenes represented in the microarray.
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Exploiting the links between 'transcriptome' and 'genome modules', the user can find biological information, or annotation, relating to gene expression.
Additional file 5: Table S5 is an expanded version of this table containing further annotation relating to gene ontology, gene function and known human diseases related to these genes.
Multiple members of the Quinoprotein Amine Dehydrogenase Domain superfamily were found in complexes rich in annotation relating to the spliceosome in one case and rRNA processing in the other.
A list of 281 a priori candidate genes with annotations related to flowering-related traits were retrieved previously from the Arabidopsis Information Resource TAIRR) version 8 (Atwell et al. 2010; Brachi et al. 2010).
Apart from metabolism-related annotations, the KAAS server also provides annotations related to genetic and environmental information processing and cellular processes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com