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We performed a detailed analysis of two gene classes, as defined in the Shigenobu et al annotation paper [ 55]: the homeobox-containing genes and the signalling-pathway genes, which are involved in the establishment of anatomical patterns and in the regulation of developmental processes in all the metazoans.
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For example, the small gene rps19 was not described in P. tetraurelia neither in the original publication nor in the re-annotation paper [ 1, 5].
These labels, referred to as "truth" annotation in this paper, are used to evaluate the performance of our method.
That said, there is clearly great importance in building and maintaining public databases of sequence data and associated functional annotation, but this paper is not about databases per se.
The labor-intensive assignments of comprehensive MeSH terms in many (although not all) research areas to individual peer-reviewed papers by biomedical experts in the USA National Library of Medicine (NLM) allows the avoidance of computational annotation of PubMed papers.
Each of them did blind annotation of 10 papers from the training and development sets that have been annotated by another curator.
Therefore, we developed new training and evaluation corpus materials for these concepts of interest, based on annotation of full papers.
The paper annotations have been used to iteratively train the machine learning component of tagtog.
PathText provides a tool for manual annotation of full papers that can be used during the model curation phase.
(2) The nuID can be directly converted to the probe sequence, and be used to get the most updated RefSeq matches and annotations (see the paper companion website).
Additionally, we use the master bibliography tables and the GO annotations to keep track of various areas that need focus, such as 'genes with no GO annotation but have papers that are selected for GO but not used'.
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