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These results confirmed that manual annotation is necessary to study the gene structures and their evolutionary relationships, particularly when large gene families are considered.
In contrast to more complex tools, no underlying protein annotation is necessary and plain protein sequences in FASTA format can be used as query templates.
While automated alignment and annotation algorithms serve to provide a good approximation of most EST identities, manual scrutiny and annotation is necessary to improve fidelity.
Annotation is necessary because typical methods used to filter the data to a manageable load, such as clustering, can further complicate the dataset, as opposed to converge the output.
Similar(56)
Manual annotation was necessary to eliminate some of the contaminant peaks that were not automatically discarded.
Thus, manual annotation was necessary.
More effective methods for functional annotation are necessary to leverage further genomic data for system-level analyses.
It is clear that empirical validation of genomic annotations is necessary and should be of the highest priority [35] [37].
The Tetrahymena research community is of sufficient size and productivity that a means to update genome annotations is necessary.
And really, no such annotations are necessary.
These additional annotations are necessary to understand the physiology, development and adaptation of a plant and its interaction with the environment.
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