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The MEDLINE and OMIM inferred disease associations can be annotated upon registration through a FACTS annotation interface.
Due possibly to their small size, genes in the CLE family were overlooked by automated annotation programs [ 30] but were subsequently annotated upon request.
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The sequences were functionally annotated based upon MG-RAST plataform using the SEED database.
Sequences were also annotated based upon the construction of logical carotenoid biosynthetic pathways, according to both currently described carotenoid biosynthetic pathways and known chemical structures (Figure 1, Table S1).
SNPs and indels were annotated based upon their location within the hg19 reference genome.
Although the scale β-keratins were annotated based upon their expression in scale tissue [ 30], it appears that the claw β-keratins are expressed at the highest level in scale tissue.
While feather β-keratins are annotated based upon the tissue in which their amino acid sequence was first determined [ 72], it has been shown that there are actually multiple β-keratin gene variants (subfamilies) expressed during embryonic development of feathers [ 9, 29, 30].
In contrast, Muslim intellectuals tended rather to ignore Averroes, though Avicenna, Suhrawardî, and other philosophers continued to be read, annotated, and improved upon.
XMetDB hence provides the means for the community to collectively build up a knowledge base over time, and it is our hope that the community will adopt the system and deposit annotated metabolism data upon publication in scientific journals.
Sequences were annotated based primarily upon phylogenetic clustering with those of demonstrated functions from the initial seed database, either in obvious clades or adjacent to them in accordance with the taxonomy of their originating organisms.
A list of 40 adult tissues to be annotated was agreed upon and includes substructures as covered by the mouse anatomy (MA) ontology vocabulary.
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