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An even greater proportion (58%) of transcripts antisense to annotated RefSeq sequences were also consistently detected, further highlighting the magnitude of antisense transcription that is not fully annotated or understood.
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Other corpora exist annotated with protein residue information either manually annotated or prepared using automatic methods.
Frequently genes are wrongly annotated, or missed entirely.
Driven by the ongoing advances of high-throughput next-generation sequencing techniques, more and more genome sequences are available that need to be annotated to understand the basis and function of processes in a cell.
These are insufficiently articulated, acknowledged or understood.
Our method could potentially be used to help annotate and understand signalling pathways in non-model organisms, using the information from model organisms as a guide for the first model generation step.
"Or understand Sioux".
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Southern hip-hop stars don't get carefully annotated compendia or lavishly presented box sets -- not yet, anyway.
Once in their backend, clipped content could be annotated, shared, or just browsed at a later date.
Having annotated data or a structured method to annotate new data is a real challenge.
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