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The average pIC50 value was calculated when multiple IC50 values were annotated on the same compound-target combination.
The standard deviations for the bioactivity values annotated on the same compound-target combination are in less than 2% of the cases higher than two pIC50 units (Additional file 3: Figure S2A), whereas more than 90% of the repeated bioactivities exhibit a standard deviation close to zero (Additional file 3: Figure S2B).
Two additional globin gene fragments (ENSPSIG00000011874 and ENSPSIG00000011856), each having the first and second exons, were annotated on the same contig.
The identified domains or motifs were added to the database if they were uniformly annotated on the same side of the membrane of the various proteins in the UniProt database.
Approximately 49% (first line) and approximately 62% (second line) of all genes (extended panel) were annotated on the same positions by BacProt and NCBI (corresponding genes), whereas approximately 20% (first line) and approximately 9% (second line) of all were found on unique positions with either BacProt or NCBI only.
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In addition, the overlap between the datapoints in the PCA of the compound descriptors (Additional file 4: Figure S3) indicates that the compounds annotated on the COX targets cover the same regions of the chemical space.
Instead, a three-exon gene (PY00180 in PlasmoDB, http://www.plasmodb.org) is annotated on the opposite strand in the same genomic location.
We also examined whether protein pairs were annotated to the same pathway based on the KEGG database, a manually curated database of pathways (Kanehisa et al., 2008).
On the other hand, GO terms annotated to the same sets of gene products are likely to be terms that describe highly related biological entities and processes.
There were multiple unigenes annotated to the same protein, which may represent different members of the same gene family.
This article is also annotated on the site.
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CEO of Professional Science Editing for Scientists @ prosciediting.com