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The immune system filter uses the annotated function of the hormones as starting point.
The name and annotated function of the identified genes that best distinguish samples based on TNF treatment (cutoff p-value <10-2,9 <10-2,9sted in Taree 2.
The name and annotated function of the identified genes (cutoff p-value <10-9) are listed in additional file 1. Hierarchical clusterization divided samples in two main branches (additional file 2).
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The annotated functions of the human genes were retrieved from the Uniprot database [ 22].
Interestingly, most of the annotated functions of the genes from these regions have been reported to be involved in host defense to plant pathogens.
To evaluate the validity of the data, the annotated functions of the identified genes were analyzed according to their Gene Ontology (GO) biological process characteristics.
Interestingly, there was much overlap between the annotated functions of the two classes of miRNAs with age-related modulation, including inflammatory disease and inflammatory response.
To decipher which tissue responses were associated with early, local bacterial infections, we analyzed the annotated functions of the 59 identified genes according to their GO characteristics.
We investigated the annotated functions of the unique core genes of one, preferably fully assembled, template isolate per unique core genome and searched for genes with plasmid or phage related functions.
The annotated functions of these genes are available online from the Scalable Vector Graphics (SVG) Figures (Fig. S1 for S. halifaxensis, Fig. S2 for S. sediminis, supplementary materials).
The annotated functions of these genes may not represent their true in vivo catalytic activities because of their low homology to characterized enzymes from other species.
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