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We assessed hind limb mechanical allodynia 15 weeks post-transplant to determine the lowest threshold force from which animals withdrew their paw.
Animals withdrew their ipsilateral paw after very low stimuli (4-5 g and 5-6 g for females and males, resp ., which did not evoke reaction in contralateral paw; for this reason we considered only the response of the ipsilateral hind paw to measure mechanical allodynia.
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As a light goes on in the house, the animals withdraw, praising the Child's newfound wisdom and kindness.
Further, there was an overall long-lasting and sustained elevation in brain reward thresholds in animals withdrawn from either 15 or 20 mg/kg/day PCP compared to rats pretreated with 10 mg/kg/day PCP or saline that lasted during the entire month of testing, as indicated by the average threshold analysis (F 3,48)=4.11, p<0.05) (see Figure 2d).
We observed an overall longer-lasting elevation in brain reward threshold in animals withdrawn from either 15 or 20 mg/kg/day PCP compared to rats treated with 10 mg/kg/day PCP or saline that was indicative of an enduring depression in brain reward function.
As a light goes on in the house, the animals withdraw, praising the Child's new found wisdom and kindness.
Randomized animals withdrawn from the study for any reason other than poor tolerability could be replaced.
When the heavy animal withdrew its foot from soft mud, the mud flowed back along the sides of the track, making an oblong impression superficially resembling a human footprint; some of the "man tracks" were formed in this fashion.
The lowest filament from which an animal withdrew from was the threshold assigned for that animal [34].
When the animal withdrew the hind paw, the mechanical stimulus was automatically stopped, and the force applied by the animal to withdraw the paw was recorded to the nearest 0.1 g.
If the animal withdrew from the training chamber during a photostimulation trial, the next trial was administered after the animal spontaneously re-entered the stimulation chamber.
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