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The preclinical potential of hybrid constructs associating cells and hydrogel has then been assessed with success in animals (mouse, rabbit).
To determine the amount of LA in whole liver tissue of fed, fasted, and 24 hr fasted animals, mouse liver tissue (n = 6 per condition, ∼20 mg per liver) was homogenized in PBS, then extracted with 1.1 ml of ethyl acetate.
When transplanted in recipient animals, mouse fetal liver stem cells differentiated into hepatocytes and cholangiocytes.
These studies also reported animals (mouse mutant M100888) with an X-linked enamel phenotype immediately suggesting mutations in the amelogenin gene (Amelx) as this is the only enamel matrix protein currently identified on the X-chromosome.
Animals (mouse and ewe) have been used as experimental models to set up the experimental protocols for freezing, grafting and culture systems because of ease in handling and similarity to the human ovary.
The dog also has more similarities in general physiology, anatomy, disease susceptibility, morphological variation and behavioural traits to humans than the most frequently used experimental animals, mouse and rat.
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Chimeric animals – mice in particular – have become a powerful tool in scientific research.
One commenter mentioned live animals (mice and snakes!) and used sanitary products (ugh).
Many small animals (mice or rabbits) have been more popular and used for cartilage defect models in previous studies15,29.
These effects of preirradiation manifest themselves, respectively, in decreased and increased mortality of preirradiated experimental animals (mice) after challenge acute exposure in comparison with that for previously nonirradiated ones.
It is shown that the predictions of the models qualitatively and quantitatively agree with the respective experimental data for small laboratory animals (mice, rats) exposed to acute/chronic irradiation in wide ranges of doses and dose rates.
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