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At levels of exposure in laboratory animals lower than that expected with standard dosing in humans, there were signs of deformation of the male and female reproductive organs with dasatinib and imatinib, but not nilotinib.
Although the distribution of genotypes in embryos was fairly close to the expected Mendelian ratio, genotyping of P0 P2 pups revealed a percentage of Kidins220ΔN animals lower than expected, indicating that some of the Kidins220ΔN pups died soon after birth.
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The Prionics Western blot detected a similar 3-band PrPres glycoprofile with molecular masses of roughly 16, 20, and 25 kDa for each animal, lower than equivalent PrP protein bands detected in animals with C-BSE.
Furthermore, dry matter intake of the 9H animals was lower than 22H animals.
In the second lactations, however, the yields of imported animals were lower than those for animals born in Thailand.
Drug concentrations measured at 20 min after injection in perfused animals were lower than in nonperfused animals in lung, heart and kidney (data not shown).
Deletions of the same site were observed in only 2/136 (1.47% CI: 0.26 4.92%) dog-1 gk10); dog-1 gk10nsgenic animals, significantransgenicthanimalstransignificantlys (t-test, P < 0.001).
In 30-week-old mice, plasma cholesterol in female WT animals was lower than in male WT animals and similar to that in male KO mice (Fig. 3B).
Although PbtO2 in the HS animals was lower than in the PS animals at most of the time points, no significant difference existed between these two groups (P >0.05).
Although glucose in the HI animals was lower than in the PI and HI-HBO animals at most of the time points, no significant difference was observed among the three groups (Fig. 2b).
The MeHg was undetectable in the brain of both treated and untreated animals within the short time frame of this experiment; however, the blood levels of MeHg in NAC-treated animals were lower than those in the untreated group.
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