An animal intervention study has confirmed the role of selenium as a cancer preventive agent [16].
We provide an RoB tool for animal intervention studies (SYRCLE's RoB tool).
Such a general tool is not yet available for animal intervention studies.
Here, the SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE) presents an RoB tool for animal intervention studies: SYRCLE's RoB tool.
As animal intervention studies differ from randomized clinical trials (RCT) in many aspects, the methodology for SRs of clinical trials needs to be adapted and optimized for animal intervention studies.
In this paper, we focus on the methodology for assessing the risk of bias in animal intervention studies.
The effect of glycemic load on β-cell function has varied in previous human and animal intervention studies.
This tool is based on the Cochrane RoB tool and has been adjusted for aspects of bias that play a specific role in animal intervention studies.
This means that some aspects of the systematic review process need to be adapted to the characteristics of animal intervention studies.
Here, we describe the results of recent human and animal intervention studies and discuss factors that might explain the variation in results.
