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Although the technology of SCNT has been applied successfully by many research teams, some SCNT animals have abnormal or lethal phenotypes, including facial abnormalities, pulmonary hypertension [ 3], contracted tendons [ 9], low birth weight [ 10, 11], as well as distinct depigmentation of the skin and hair [ 12].
We found that hda-1 (RNAi) and hda-1 (cw2 ) animals have abnormal patterns of egl-13 :: gfp and lin-11 :: gfp expression.
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Seventeen (77 %) animals had abnormal neurological findings and five did not.
Once the animals started having abnormal signs, saliva samples were sent for rabies confirmation by nucleic acid sequence based amplification (NASBA) as previously described [ 15].
In Stage 36 embryos, of 22 nerves imaged in CTL MO animals, one had abnormal morphology and of 14 nerves imaged in morphants, 12 were abnormal (Fisher's exact test P < 0.0001).
Animals perinatally exposed to certain environmental organohalogens such as many of the PCBs and dioxins have abnormal thyroid function and neurologic impairment.
Do you have abnormal body hair?
Cells affected by diseases have abnormal levels of gene activity.
Child might have abnormal lung airways.
These mice have been suggested to therefore be appropriate as an animal model of human spinocerebellar ataxia, and recent studies of these animals have demonstrated an abnormal glutamic acid to γ-aminobutyric acid (GABA -A receptor function and expression in the cerebellar and cerebral cortices resultinGABA -Aan abnoreceptor type VGCC activity [7], [8], [9], [10].
By contrast, the 20°C-cultivated AFD-ablated animals had two abnormal behavioural phenotypes: cryophilic movement is to migrate to colder regions than wild-type animals and athermotactic movement is random movement on the thermal gradient (Fig 3A).
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