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The vaccinated animals controlled disease following challenge with a heterologous SHIV.
Culling will only take place in the localised areas where it will make a difference, the number of licences will be limited, the licence will specify the maximum number of badgers that can be controlled, and the number of animals controlled will be monitored to guard against local disappearance".
BACKGROUND: We reported previously that while prolonged tenofovir monotherapy of macaques infected with virulent simian immunodeficiency virus (SIV) resulted invariably in the emergence of viral mutants with reduced in vitro drug susceptibility and a K65R mutation in reverse transcriptase, some animals controlled virus replication for years.
After challenge with SHIV 89.6P, MVA-boosted animals controlled peak challenge viral loads to less than 2 x 10 6) copies/ml (a level significantly lower than that seen with VSV-boosted animals and lower than those reported for other vaccine studies employing the same challenge).
These 3 animals controlled their blood stage infections below 1% parasitemia without drug therapy.
One of the two infected animals controlled its initial parasitemia at 1% and then self-cured, while the other exceeded 2% parasitemia on day 12.
Similar(47)
"We're asking: 'How can we give animals control over their lives?' " Dr. Reiss said.
The exercise was fully under the animals' control.
Animals (Control of Experiments) Act (Cap. 71 03).
Animals (Control of Experiments) Ordinance [Cap 2].
Young, untreated cage control animals (Control) were also assessed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com