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We identified significant changepoints in all sites and proxies, suggesting fundamental and widespread changes in the terrestrial biosphere.
Such observations underscore the importance to understand how genetic perturbations lead to the global reorganization of nuclear architecture, chromatin structure and widespread changes in gene expression.
More severe and widespread changes in the brain are related to the massive declines in memory functioning seen in Alzheimer disease, also known as Senile Dementia of Alzheimer Type or SDAT (see memory abnormality).
But the pronounced changes in the environment that marked the end of the last ice age occurred at the same time, including abrupt warming of the planet, rapid retreat of the glaciers and widespread changes in vegetation.
In very practical and tangible ways environmental education can resolve this disconnection and deliver real and widespread changes in knowledge, behaviour and on-the-ground action.
Overall our data suggest that altering Myc levels induces varied and widespread changes in methylation patterns.
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It is a low-risk and high-reward opportunity to catalyze the personal and organizational development of those around them and effect long-lasting and widespread change in their immediate community within their two short years at SOM.
If there is to be a large and widespread change in employment patterns in this group in the UK, a variety of vocational pathways are likely to be required to meet a range of needs.
Spelman warned this week that drought could be "the new norm" for the UK, and that widespread changes in behaviour would be needed to cope.
Interestingly, it has recently been shown [ 36] that a neuromodulator cocktail including CCh, NA, serotonin, histamine, dopamine and orexin applied to cortical networks similar to those used here, both suppresses network synchrony and drives widespread changes in gene expression, which do not fully revert even when synchrony spontaneously reemerges.
It also led to an unprecedented national discussion about sexual violence and calls for widespread changes in cultural attitudes and policing, and legal reform.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com