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ADP-ribosylation factor-like (ARL) proteins are small GTPases that undergo conformational changes upon nucleotide binding, and which regulate the affinity of ARLs for binding other proteins, lipids or membranes.
To recall a frequently used metaphor, these effects can be described as a process of capsularisation of metropolitan areas (De Cauter [2004]): the city is fragmented into a multiplicity of closed or, in any case, controlled spaces, that defend the occupants from unwanted stimuli and which regulate their behaviour.
This is indeed supported by the fact that Sdha has 13 lysine-acetylation sites that are deacetylated by Sirt3, and which regulate its activity.
Ethylene-responsive element binding factors (ERFs) are members of a novel family of transcription factors that are specific to plants and which regulate nuclear gene expression under various stress conditions.
Among the most exciting findings was probably the discovery of protein complexes at TJs which are highly conserved through evolution and which regulate cellular polarization in different organisms and various cell types.
VCP, PLAA or UDF1L, which promote release and degradation of nascent proteins from the ribosome and which regulate SG assembly, colocalize with OP-puro-labeled peptides (Supplementary Figures S5J L).
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With his colleagues at the Paterson Institute for Cancer Research in Manchester, his rigorous work laid the basis for the present concept of the stem cell niche, the environment in which stem cells are found and which regulates stem-cell fate.
"We also have a planned landmark preservation overlay district that indicates any property that has historical significance and which regulates any changes to a structure on that property," he said.
Evidence was obtained for adverse effects on cellular maturation, as shown by perturbations in the ornithine decarboxylase/polyamine system, which is controlled partially by beta adrenergic input and which regulates macromolecule synthesis in developing cells.
The effects of vitamin D are mediated through its receptor (VDR), which is known to be a ligand-activated transcription factor and which regulates target genes.
X11β is a neuronal adaptor protein that is enriched in the Golgi and which regulates APP processing and Aβ production (45– 50).
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