Exact(42)
All isolated lungs were perfused (constant flow, 300 ml/min) and ventilated for 1 hour with pressure control ventilation at either 23 cmhigh-pressuressure, injurious ventilation) or 11 cmH2O (low-pressure, noninjurious ventilation) peak static pressure and positive end-expiratory pressure of 3 cmH2O.
The animals were connected to a Servo Ventilator 300 (Siemens-Elema, Solna, Sweden) and ventilated for one, two or four hours in a pressure-controlled time-cycled mode (n = 9 to 10 per group), at a fractional inspired oxygen concentration (FiO2) of 1.0, inspiration to expiration ratio of 1 2 and frequency of 20 to 30 breaths/min to maintain normocapnia.
Piglets were intubated with a PVC-cuffed tracheal tube, and ventilated for 48 hours under sedation and neuromuscular blocking agents.
Methods: Patients admitted to a large UK teaching hospital during the trial period and ventilated for ≥ 5 days were included in the study.
A randomized controlled animal study found ischemic tracheal lesions in animals intubated and ventilated for 48 hours despite continuous control of Pcuff (< 30 cmH2O) [67].
This effect could in part explain the findings in the present study since our ICU patients had already been admitted and ventilated for 12 ± 5 days before they were studied.
Similar(18)
The ratio of proliferating mesenchymal and epithelial cells did not significantly differ between non-ventilated pups and pups ventilated for 8 and 12 h, respectively (0.73±0.05 vs. 0.65±0.03 and 0.67±0.1).
Mice were treated with either sterile saline (vehicle), 1 µg Ang-1 or 4 µg Ang-1 per animal at initiation of HVT-ventilation and subsequently ventilated for 5 hours.
However, this choice was based on published reports [10, 11], was validated in a population of patients briefly anaesthetized and mechanically ventilated for elective surgical procedures and was subsequently used in a previous report [3].
Patients without infectious lung pathology by clinical and radiological criteria who were intubated and mechanically ventilated for at least 5 days served as a control group.
Consecutive children aged between 7 days and 18 years admitted to the PICU and mechanically ventilated for at least 24 h were eligible.
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