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The aim of this study was to assess bone microarchitecture and turnover in a mouse model of high-fat diet induced obesity.
It is likely that osteoclasts and their precursors secrete many more factors that interact with immune and other cells to affect bone volume and turnover in a variety of bone disorders.
These changes correspond to a sizable reduction in tyrosine 397 phosphorylation (pY397) of FAK, which also regulates costamere-component expression and turnover in a load-dependent fashion [ 27, 29].
Through this interaction, and its interactions with the Arp2/3 complex and the other binding partners mentioned above, Abp1 may influence actin-filament assembly and turnover in a number of ways.
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In addition, specific knockdown of either ISG15 or UbcH8, ISG15-specific conjugating enzyme (E2) restores protein polyubiquitylation and turnover in A-T cells.
However, we cannot rule out the possibility that the free ISG15 pool also plays an independent role in regulating protein polyubiquitylation and turnover in A-T cells.
Studies are underway to establish the significance of ISG15-mediated impairment of protein polyubiquitylation and turnover in A-T pathogenesis (e.g. neurodegeneration) in our laboratory using ATM knockout mice.
Together with ephrin ligands, these receptors coordinate tissue and organ patterning, cell positioning, and cell survival during development and tissue turnover in a cell type-specific manner (Xi et al., 2012).
One limitation of the standard measure of turnover (leavers in the year/total workforce) is that over the time period under measure it does necessarily differentiate well when comparing units with high and repeated turnover in a few posts, and those with lower turnover in more posts [ 13, 17].
"It is a quick win to help boost a flagging home ownership sector and stimulate turnover in a market where transaction levels are now three times slower than in the 1980s.
The present study investigated the effect of EPF on bone mineral status and bone turnover in a rat model of human relatively high exposure to cigarette smoke.
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