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We were unable to test whether adverse effects incidence was different between trials with dose titration and trials using a fixed dose.
For example, a meta-analysis addressing pain might include trials measuring pain on a visual analogue scale and trials using a five point numerical rating scale.
However, it seems that the paediatric consortia generated by the FP7 paediatric projects are conducting these studies and trials using a limited amount of money in comparison with the recognised cost of paediatric trials in an approved PIP which is estimated to be three to four times higher [ 2, 21].
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To test whether the infants habituated to stimuli in the familiarization phase, we compared the sum of looking times for the first and second trials with that for the third and fourth trials using a two-tailed paired t-test.
Here, we re-examined this issue by comparing saccades and nogo trials using a rapid event-related fMRI design in which saccade trials were presented twice as frequently as nogo trials to make the saccade response more prepotent.
CTGF is therefore an attractive target for the treatment of pulmonary fibrosis, and clinical trials using a monoclonal anti-CTGF antibody are under preparation.
The parameters for simulating these characteristics were obtained by analyzing the longitudinal ADAS-Cog data from the placebo arms of ADCS and CAMD trials using a generalized mixed-effects model approach.
The percentage accuracy of judgments constituted the measure of lie detection performance, which was compared in experiment 1 for opinion-consistent and -inconsistent trials using a paired-sample t test.
We performed an extensive search and systematic review of both completed and on-going trials using a number of databases and by checking reference lists.
The antitumour effects of fulvestrant have been demonstrated both in preclinical studies and in clinical trials, using a number of prognostic and predictive markers.
All rats were then exposed to four paired and four unpaired trials using a "ABBAABBA" design.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com