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Conversely, dephosphorylation at the end of mitosis should promote interactions between nucleoporins and thus NPC assembly.
Our results are consistent with these reports and thus, NPC joins the list of the tumors that express Cripto-1.
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NPC is too infrequent to evaluate before age 30 and after age 75; thus, NPC patients younger than 30 and not younger than 75 were not included in the analysis.
Nasopharyngeal carcinoma (NPC) has an extremely unbalanced endemic distribution, and it is prevalent in southern China, with Chinese accounting for 40% of all incident NPC cases worldwide [1]; thus, NPC is also known as the "Cantonese cancer".
Thus, NPC cells were transfected with Jab1 siRNA, and cell survival was measured by the colony formation assay.
Thus, NPC-TW01, -TW02, -TW04 and HK1 NPC cell lines were transiently transfected with LMP1-expressing plasmid, and pro-IL-1β mRNA and protein levels were determined.
A proof that is a Cartan-Hadamard manifold (and thus a global NPC space) may be found in [19].
Genetic alterations have been reported in NPC, and our recent findings showed that one such alteration, c-Jun activation domain-binding protein-1/constitutive photomorphogenic-9 signalosome (Jab1/CSN5), which negatively regulates p27, is overexpressed in this disease [ 7] and thus contributes to NPC resistance to radiotherapy and chemotherapy [ 8, 9].
Interphase NPC assembly seems to rely on steps that occur on both the cytoplasmic and the nucleoplasmic side of the nuclear envelope and thus nuclear translocation of NPC components through already existing pores might be critical for new NPC assembly in intact nuclei.
This finding is consistent with the original idea that hexanediols disrupt the FG FG interactions within NPCs and thus increase their permeability.
Given these striking differences in gel structures, it is remarkable that the NQ-rich FG domains from scNup100p or scNup116p can functionally replace the Nup98 FG domain in reconstituted Xenopus NPCs and thus support facilitated passage of Xenopus NTRs (Hülsmann et al, 2012).
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