Patho-physiologies related to skin are diverse in nature such as burns, skin ulcers, atopic dermatitis, psoriasis etc. which impose severe bio-medical problems and thus enforce requirement of new and healthy skin prepared through tissues engineering methodologies.
CCSMs are able to specify which data objects need replication and the enormous extensibility of iRODS with user-specific rules enable CCSMs to specify those objects that need M replicas for N years being automatically executed and thus enforced.
We apply weighted sparse coding for dictionary learning, and thus enforce both sparsity and locality, since locality may be more important than sparsity, as suggested by Wang et al. [7].
Cbl, through activities including its function as an E3 ubiquitin ligase, limits many of the molecular interactions and events that could otherwise drive T cell differentiation, and thus enforces the requirements observed in canonical pathways of pre-TCR/TCR signaling.
Overall, this elegant study establishes that Csk controls the size of the active pool of Lck and thus contributes to set the TCR signaling threshold and thus enforces TCR affinity discrimination in peripheral T cells.
Loss of CDK activity prevents the phosphorylation of CDK target proteins, most prominent among them the retinoblastoma (Rb) tumour suppressor protein, which remains hypophosphorylated and thus enforces the restriction point and concomitant growth arrest in G1.
Additionally, a Lys residue forms hydrogen bonds to both the 2′- and the 3′-hydroxyl groups of the cofactor's ribose moiety and thus enforces a proper orientation of the nicotinamide ring to allow a pro- S hydride transfer only.
The BCG-induced depression-like behaviour depends on the formation of TNF-α and IFN-γ that cause an up-regulation of indoleamine 2,3-dioxygenase and thus enforce the kynurenine pathway of tryptophan utilization (Moreau et al., 2008; O'Connor et al., 2009a,b 2009b).
Design-by-contract predicts a scenario where once established interfaces remain intact during evolution and thus enforces functional continuity [ 14, 15].
Therefore, this signal transduction pathway is only active when both ABA>0 and ACC>0, thus enforcing a logical 'and' operation on the signals.
