Sentence examples for and thus activate from inspiring English sources

Paradoxically, however, basal caspase activity is required to cleave and thus activate DIAP1, which in turn inhibits caspase activity levels, resulting in the oscillatory maintenance of the caspase activities below the threshold level (Ditzel et al., 2008).

Because of their ability to cleave and thus activate specific PARs, endogenous proteases play a specific role in CNI.

We use the perfusion culture system to produce FSS exerting on human bone marrow-derived mesenchymal stem cells (hMSCs) and thus activate ERK1/2.

Furthermore, if they are not conducted by professionals accustomed to referring also to positive aging effects, this type of intervention could have an effect opposite to that expected and thus activate the stereotype threat in older adults [49].

It is indicated that the IgG1 hinge could coaggregate FcɛRI with the inhibitory receptor FcγRII on mast cells and basophils, and thus activate the inhibitory signaling pathway of FcγRII.

Illuminating them with blue light leads to an influx of calcium ions, just as it does in the neurons; in the kidney cells, this does not trigger an electrical pulse but allows a so-called transcription factor, NFAT, to move into the cells' nuclei, bind to certain DNA sequences called promoters, and thus activate certain genes.

Following photon capture by rhodopsin, Grb14 moves to rod outer segments, where it is tyrosine phosphorylated by light-activated Src and binds to PTP1B: binding inhibits PTP1B phosphatase activity and thus activates the IR [ 10].

In cellular and in vitro binding studies, the binding of Rho to the Drf GBD domain exposes the FH2 domain and thus activates actin-nucleating activity [14], [17], [22], [24].

Meanwhile, DC120 attenuated the inhibitory effect of AKT on CRAF by decreasing phosphorylation of CRAF at Ser259 and thus activated the mitogen-activated protein kinase (MAPK) pathway.

Cells with activated BXB-ER (and thus activated MEK/ERK Fig. 1A and [35]) displayed a heterogeneous texture with more dense chromatin aggregates (Fig. 1B, arrows) and discrete chromatin foci along the nucleolar periphery and nuclear lamina (Fig. 1B, arrowheads).

In large part, thrombin initiates cellular effects by cleaving and thus activating a novel set of Proteinase-activated receptors (PARs 1 and 4; but not PAR2), that are members of the G-protein-coupled receptor (GPCR) superfamily [ 4- 8].