The phrase "and this makes it difficult" is correct and usable in written English.
You can use it to indicate that a certain situation or factor is causing challenges or complications.
Example: "The lack of clear communication between team members is a major issue, and this makes it difficult to meet our deadlines."
Alternatives: "and this complicates matters" or "and this poses a challenge."
However, its results are sensitive to outliers and this makes it difficult to assess the significance of results.
And this makes it difficult to know how to feel about the latest wave of investigations.
Several aspects of the pathogenesis are not elucidated and this makes it difficult the design of specific treatments.
One is that the NV center emits light in all directions, and this makes it difficult to collect.
BPEL is a powerful language but lacks a widely accepted formal semantics, and this makes it difficult to formally validate the correct execution of BPEL implementations.
The temperature of the crystallizer increases during ultrasonication and this makes it difficult for the temperature controller of the crystallizer to track a set temperature trajectory precisely.
We were unable to identify a single activity or mechanism of injury responsible for this increase, and unfortunately this makes it difficult to suggest implementation of any specific preventive measures.
This makes it difficult and unappealing for them to challenge the prevailing way of doing things.
The Kochs continued to disperse their money, creating slippery organizations with generic-sounding names, and this made it difficult to ascertain the extent of their influence in Washington.
Both opinion-writing and reporting styles had changed dramatically in the course of the fifty years my database covered, and this made it difficult to find patterns when extracting, say, the names of judges involved.
We also observed very low CRP values in patients, and this made it difficult to show further reductions and correlations.
