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From a global perspective, right now we are building up a huge problem in the west with our net debt and this is a substantial problem for development.
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Adulteration of Dutch chicken meat with proteins from pigs and cattle is a substantial problem.
BACKGROUND: Obesity is a substantial problem in the Veterans Health Administration VHAA).
Low patient adherence is a substantial problem in therapy.
Obviously, if the car won't start or catches fire, then it is a substantial problem.
Bullying in school is a substantial problem for Greek youth.
Publication bias is a substantial problem throughout science.
This is a substantial upgrade".
This is a substantial grievance.
What is less clear is whether the trade imbalance will prove to be a substantial problem.
The recovery of the otters proved not to be a substantial problem for the Navy.
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