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Its contemporary architecture – all clean lines and enormous windows – is designed to make the most of the lakeside location, and this culminates in an enormous decking area offering incredible views by the water.
Recognition of PAMPs by TLRs activates intracellular signaling pathways and this culminates in the induction of inflammatory cytokines, chemokines, and interferons and upregulation of co-stimulatory molecules.
Possible mechanisms of metabolic stress-induced β cell apoptosis in T2D include endoplasmic reticulum (ER) stress (Kharroubi et al., 2004), oxidative stress (Carlsson et al., 1999) and ceramide production (Shimabukuro et al., 1998), and this culminates in activation of the intrinsic or mitochondrial pathway of apoptosis (Cunha et al., 2012, Gurzov and Eizirik, 2011).
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In 2004 Parma were declared insolvent and this culminated in the club's relegation from the top flight in 2008.
He was very anxious to provide some legacy of his investment genius which might be useful to others and this culminated in the production of a book, There's Always Something To Do The Peter Cundill Investment Approach.
In the late 90's there was a growing acceptance that both theory-theory and simulation theory were partially right and partially wrong, and this culminated in a general acceptance of some sort of hybrid theory (e.g. Nichols & Stich 2003; Goldman 2006).
From 1142 onwards, sluices were constructed to prevent flooding by the sea, and this culminated in the Great Sluice, which was constructed in 1766.
The creation of this cross-Humber authority was unpopular and this culminated in the local government review in the 1990s, which saw Humberside abolished and the northern part form two unitary authorities.
In 30% of our participants, the lumbar T-score was higher than hip T-score and this culminated in poorer hip diagnoses in 9.2% of participants.
Several GRN nodes emerged from genes upregulated in the TSA-NT group and this culminated in the upregulation of a number of developmentally important genes including SNRPN, PRKAB1, ARRB2, GADD45G, and GEMIN4.
In 2017, after over a year of research and development, this culminated in the launch of OmiseGO, the crowd-funded blockchain division tasked with creating the OMG network.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com