The phrase "and therefore substantially" is correct and usable in written English.
It can be used to indicate a conclusion or result that is significant or considerable in relation to a preceding statement.
Example: "The new policy has improved efficiency, and therefore substantially reduced costs for the company."
Alternatives: "and thus significantly" or "and consequently greatly".
But much larger — and therefore substantially overlapping — majorities, usually in the seventy-per-cent range, say that they are convinced by the mutually exclusive arguments of both sides.
Amnesty International's report on the use of the death penalty in 2011 uses publicly available data and therefore substantially undercounts many countries (such as China and Iran).
Released six weeks after Pearl Harbor (and therefore substantially completed well before the attack), this spirited satire of high-minded (or, in the Sturges idiom, "deep dish") Hollywood may have struck audiences in 1943 as suddenly out of date, a holdover from the prewar world.
Utilization of the full detection volume would require larger T-connections and therefore substantially increase the dead volume.
The presence of the nanoparticles in the nanofluid increases the thermal conductivity and therefore substantially enhances the heat transfer characteristics of the nanofluid.
Too many experts addressing this issue assume it's a pipeline problem, meaning there aren't enough female tech professionals to begin with to mentor young women, and therefore substantially fewer women are pursuing tech education at a young age.
The observed cumulative incidence rate of hypospadias of 0.6% does not include mild glandular and coronal cases and is therefore substantially lower than the prevalence of 4.7% that was reported in a study of newborn boys from the Copenhagen area [ 30].
We observed that they form hydrogels as well and might therefore substantially contribute to the NPC's cohesive mass.
Indeed, the extent of tissue injury in the intestine is directly correlated with the number of circulating neutrophils and is therefore substantially greater in males.
The computed genetic distance between RHV-339 and HCV in the structural regions ranged from 67%to77%and65%to70%to 70% in the non-structural regions, and was therefore substantially greater than that between HCV and NPHV.
A detailed understanding of the structure, transport mechanism and conformational changes of PepT1 and PepT2 would therefore substantially improve efforts to utilize these transporters for improved drug delivery, distribution and retention (Brandsch, 2009).
