The marked, general uncoupling between transcriptome and translatome gene expression changes allowed us to propose a biological model by which the machineries responsible for mRNA availability in the cytoplasm and for mRNA engagement in translation lack overall dependency, therefore questioning the notion of continuity in the control of the flow of gene expression.
It is noteworthy that Arnold Bloom (Kosola and Bloom, 1996), one of the prominent physiologists in this field, and others have reported that inhibition of nitrate uptake by nitrate was not competitive, therefore questioning the mechanism of chlorate transport.
However, recent advances in post-genomic biology are indicating that polypharmacology may be a necessary trait for the efficacy of many drugs, therefore questioning the 'one drug, one target' assumption of current rational drug design.
Therefore, questioning the top management offers a different approach to measuring safety culture and providing aggregated organisational data.
Therefore, questioning self-rated health alone can have a confounding effect.
Using Tag-seq, 1,123 RT had greater SBS in healthy than in cancer cells, therefore questioning the reliability of this result.
We were therefore questioning the value of interpersonal continuity instead of taking it for granted, and we assumed we would see similarities and differences more clearly by comparing patients' experiences with regular and unfamiliar GPs.
We report here that RIP1 is a crucial mediator of canonical NF- κB activation in L929 cells, therefore questioning the relative cytoprotective contribution of RIP1 ubiquitination versus canonical NF- κB activation.
In this study, we found that RIP1 is a crucial mediator of canonical NF- κB activation in L929 cells, therefore questioning the relative contribution of RIP1 ubiquitination versus canonical NF- κB activation as cytoprotective events against TNF-induced necroptosis.
A second A. thaliana protein sharing 24.0 and 19% identity with ICBP90 and NIRF, respectively, possesses a PHD, a RING finger as well as a G9a domain, but not in the order found in ICBP90, therefore questioning its membership to this family.
