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Transcriptional studies of the mia operon identified the protein product MiaB as possessing the common CX3CX2C Fe S cluster binding motif but lacking conserved SAM binding motifs; this led to the conclusion that MiaB likely catalyzes the thiolation of iA-37 but not the methylation step, and therefore necessitated a third enzyme to carry out the final methylation event.
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At the same time Schelling insists there must be that against which freedom can be manifest — a being which is not free and is therefore necessitated — for it to be meaningful freedom at all.
The development of implantation technology for SiC has therefore necessitated several changes from mainstream silicon implantation technology.
Hence the ontological distinction between the uncaused Principle and Its effect does not lie in existence as such, but in one of its modes: the uncaused Principle is necessary as regards existence, while everything else is always possible as regards existence: i.e., it exists insofar as it is necessitated and therefore necessary by virtue of something other.
Lesions were progressive involving fasciae and muscles and necessitated 2 episodes of surgical debridement during the first month.
Postoperative recovery was slow and necessitated hemodialysis and prolonged antibiotic therapy and intradialytic parenteral nutrition.
The main toxicity was haematological, with neutropenia and thrombopenia, that necessitated course delay and dose reduction.
The discovery of oil and gas necessitated cheaper routes of water transportation to markets in the eastern and northern United States.
Their conviction that human reason could acquire knowledge of supersensible entities, including the soul and God, necessitated, in Kant's view, a "critique".
My education explicitly encouraged and indeed necessitated open-mindedness, self-reflection, and curiosity.
Accordingly, as trade unfolded, imbalances in trade (imports and exports) arose and this necessitated that gold be transferred between nations (in boats) to fund these imbalances.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com