Therefore, more functional roles of CIP2A in cancer progression need to be explored.
Therefore more functional polymorphisms of this region should be investigated in other independent studies using larger samples.
What are the features of a realistic background model that allow for the identification of statistically significantly recurrent and therefore more likely functional alterations?
25 As an important intermediate product in OCM, homocysteine may be a better indicator of methyl group supply and therefore more accurately reflects functional transmethylation in genome-wide methylation.
Putting the recipes directly in the apps themselves makes it far more likely that they will be used, and giving them to users of, say, connected devices will make those devices more functional, and therefore more likely that users beyond early adopters will buy them. .
To target those patients at greater risk of functional decline and therefore more likely to benefit from a functional maintenance program, the HARP tool was utilised to identify those at intermediate or high risk of functional decline [ 6].
At least 38% of these SNPs are from transcribed genomic regions and therefore more likely to include functional variants.
Polymorphism PTGS2.10335 also showed a marginally significant association, but PTGS2.9850 and PTGS2.10335 were in tight LD (r=0.79), and we will focus our discussion on 9850, as it is before the poly-A signal, and therefore more likely to have a functional relevance, while 10335 is after.
The regions were compared to the Database of Genomic Variants tracks (http://projects.tcag.ca/variation/) in the UCSC Genome Browser, Feb 2009 hg19) assembly (http://genome.ucsc.edu/), to ascertain if they were novel and therefore more likely to have a functional effect in this family.
As well as examining site preference in superfamilies, we also investigated whether the site coverage tends to be lower for a functional subfamily than for superfamilies i.e. lower site coverage for relatives sharing similar functional properties and therefore more likely to have similar protein partners.
