However, the situation is totally different in erythroid cells, which express a heme synthetic ALAS2 isoform that contains a 5′ IRE and is subject to IRP repression and a specific FPN1b transcript that does not have a 5′ IRE and can therefore evade repression by IRPs when there is cytosolic iron deficiency (65).
But Rubio decided that the question was hostile and that he could therefore evade it.
They must therefore evade neutralization by other means.
We could speculate that studies using only one focus group, a number that goes against the rules of thumb offered by these guidelines, is simply too hard to justify and explanations are therefore evaded.
It is possible that the interaction is too weak or transient, and that it therefore evades detection in our system, even though we can detect interactions between the two proteins when both are overexpressed.
As phosphorylation of GSK3 by Akt can inactivate its kinase activity 64, which could lead to reduced Klf4 phosphorylation by GSK3, therefore evading Fbw7-mediated proteolysis.
However, not all tumour cells are sensitive to such activation, and some of them show resistance to this pathway by means of several mechanisms, and therefore manage to evade the host immune system, hence becoming resistant to chemotherapy.
In contrast, the atl mutant would release intact muropeptides, easily detected by PGRP-SA, and therefore would be unable to evade detection by the innate immune system.
Thus, types II, III and IV patients, and even symptom-free carriers, could develop a subset of subtle and progressive pancreatic/metabolic defects that may evade detection, and therefore, proper monitoring.
