The phrase "and therefore alteration" is not correct and usable in written English as it lacks clarity and context.
It could be used in a context where you are discussing changes or modifications that are a result of a previous statement or condition.
Example: "The initial plan was flawed, and therefore alteration was necessary to ensure success."
Alternatives: "and thus modification" or "and consequently change".
Inflammation is present in metabolic syndrome and therefore alterations in albumin transport across endothelial cells are likely to be present.
In Arabidopsis flowers, senescence has been connected with low levels of ascorbic acid and therefore alterations of the endogenous levels of both giberelic and abscisic acid [ 47].
One miRNA can target hundreds of mRNAs and, therefore, alterations in a single miRNA can have dramatic effects on cell biology.
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression and therefore alterations in miRNA levels may be involved in the deterioration of beta cell function.
Neuronal development involves a number of different processes and therefore alterations in the expression or localization of proteins during development may indicate a role in these processes.
The effect of several chemotherapeutic drugs may be mediated through DNA damage and induction of apoptosis (Gewirtz, 2000), and therefore alterations to TP53 and hence p53 protein function could result in relative resistance to these agents.
Absence of ClC5 is related to a dysfunctional endosomal acidification and therefore alterations in the reabsorption and the endocytosis, leading to a renal tubular disorder called Dent's disease.
Furthermore, organic anion transporters are known as uptake transporters for HIV-PIs, and therefore alterations in these transporters could result in lowered drug seen by a cell (Janneh et al, 2008).
Indeed, protein protein interactions, the foundation of cellular molecular function, are potentially affected by changes in amino acid sequence, and therefore alterations to DNA coding regions may have deleterious effects on the biochemical functions of a protein (Goodman 1963; Wray et al. 2003; Fraser et al. 2004).
