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Compared to normal individuals, obese individuals have noted pathophysiological alterations which may alter the toxicokinetics of xenobiotics and therefore alter their toxicities.
It is important to investigate connections and pathways whose interactions might be disrupted and therefore alter collagen structure and lead to the development of pathology.
Activation of the 5-HT2B receptors may stimulate cell proliferation and angiogenesis and therefore alter the vascular system of the dura mater, which may result in a higher susceptibility for migraine.
The phase transformation of the salt to the free form of the drug is extremely undesirable, since it will change the solubility and dissolution rate of the active substance and therefore alter the bioavailability of the final product.
However, the artificial defects will change the surface integrity and therefore alter the nature of fatigue damage, and thus, the fatigue damage in the presence of artificial defects in literature may not reflect the true mechanism of real-life fatigue processes.
However, several studies investigating polymorphisms in genes encoding for proteins interacting with type V collagen showed that it is important to be aware of possible connections and pathways whose interactions might be disrupted and therefore alter collagen structure and its functionality and lead to increased or decreased risk of Achilles tendinopathy.
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The dopants act as attractors of OH groups, making the material prone to oxidation, and therefore altering its affinity towards Na.
Human activities, such as land cover change, urbanization, and water conservation projects, impose significant impacts on runoff through changing the runoff generation condition and therefore altering the regional hydrologic cycle (Zhang and Wang 2014).
Some 19th-century writers regarded Boone's sympathy for Indians as a character flaw and therefore altered his words to conform to contemporary attitudes.
ICA and, more robustly, ICT directly modulate MDSC signaling, and therefore altered the phenotype and function of these cells, both in vitro and in vivo.
NCOR2 and CITED2 both function as regulators of transcription and therefore altered gene expression patterns could be expected by their deregulation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com