Sentence examples for and therefore activation of from inspiring English sources

The azide mutagenesis could have resulted in either a mutation in the repressor binding site for Cbf-K or a mutation to the repressor domain, allowing for an active CBF-K and therefore activation of the downstream genes that lead to the freeze survival properties expressed by FR lines.

To reduce these side effects, the β2 agonists are usually given by inhalation, which increases pulmonary exposure to the drug while lowering systemic exposure and therefore activation of cardiac receptors.

Together, these results indicate that oncogene-induced senescence in murine fibroblasts and lung epithelial cells is not associated to an ongoing DNA damage response and, therefore, activation of p53 and establishment of senescence occur independently of Atm.

Constitutive activation of NF-κB is another hallmark of cHL and could promote the expression of IL-13 and therefore activation of STATs [ 15].

Ligation revealed an increase in 4E-BP1 phosphorylandon (and therefore activation of mTOR) in 3 day groups, as shown by the presence of a higher molecular weight band.

Immunoblotting of phospho-S6 ribosomal protein, a downstream component of the mTOR substrate S6K1 in glandular homogenates revealed activation of S6K1 (and therefore activation of mTOR) in only the ligated state in the 3 day group.

Binding of rcTA, and therefore activation, is induced by addition of cumate (Fig. 1D).

Again binding of cTA, and therefore activation, is regulated by addition of cumate (Fig. 1C).

Conversely EGF treatment of a serum-free epidermal culture model resulted in decreased differentiation [ 2] and an elevated expression of EGFR in differentiating cells, and presumably therefore activation of EGFR signaling, resulted in hyperproliferation [ 22].

From recent studies, however, it was found that AF has various degrees of organization, and therefore activation during AF can be analyzed by spectral analysis.

Competent electron-transfer chain complexes have been recognised as sensors of apoptosis (Lemarie and Grimm, 2011); therefore, activation of OXPHOS by DCA may release sorafenib-resistant HCC cells from an anti-apoptotic status.