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Post-translational modifications of histones at specific residues help to determine chromatin structure and therefore accessibility to gene promoters and regulatory regions.
Moreover, patients often have to pay out of their pocket for diagnostic tests, and therefore accessibility to tests is limited due to the financial means of the patient.
Differences in the subcellular localization, and therefore accessibility, of these compounds to PLD1 and PLD2 within these cells may also explain this discrepancy.
Not only does Na,K-ATPase modulate signaling molecules that are thought to be central to medulloblastoma pathogenesis, but also due to its plasma membrane localization and therefore accessibility from the extracellular side it makes a very attractive pharmaceutical target.
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I believe that everyone deserves the opportunity to have an education and better their lives; therefore, accessibility is vital.
Therefore, accessibility, convenience and safety of PA facilities should be assessed in future research on the physical environment.
Specific binding capacity of a diol-containing dye Alizarin Red S in the gels at pH 7.0 coincided with the content of immobilized NAAPBA indicating the 1 1 stoichiometry of the reaction and, therefore, good accessibility of the boronic acid ligands for water-soluble diols.
Any 3D structural information is expected to be destroyed well before the polypeptide reaches the catalytic chamber and therefore surface accessibility may be irrelevant in such cases.
Moreover, this information could be combined with studies concerning the secondary structure and therefore the accessibility of the target-mRNA, which also influences the potential of RNAi.
Considering that PKG-CA has a smaller molecular weight compared with the holoenzyme and therefore the accessibility (to targets) may or may not be the same, we proceeded to verify the effect of PKG-CA on Kir6.2/SUR2A channels using purified PKG Iα holoenzyme (PKG).
Here, it should be noted that crystallinity may also affect cellulase adsorption [ 26, 27] and, therefore, cellulose accessibility [ 15, 21, 28].
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