Additional comments from Goodman et al. in their letter raise the possibility that the number of samples below the limit of detection (LOD) in our study sample could be higher than in the full study population and could thereby effect the results.
In our dataset, about 38%% of the isomiRs were variant at the 5' end, which should change the seed sequence (2 7 nt at the 5' end), and thereby effect changes in target mRNA and possibly miRNA function [ 39].
An individual miRNA can influence hundreds of gene transcripts to coordinate complex programs of gene expression and, thereby, effect global changes in the physiology of a cell [ 2, 3].
A generalized mental arousal is thereby effected.
A low cardiac output or a high metabolic rate augments the venous content of carbon dioxide, and thereby the effect on shunt on PaCO2.
The implementation of the training needs more attention since this may improve adherence and thereby the effect size [ 24].
The original peak value,, can be estimated from using parameters and, and thereby the effect of scrambling can be practically avoided.
Second, metformin may be more effective in individuals with a higher A1C at baseline, and thereby the effects of genotype on response might be easier to detect in the disease setting.
In addition, we found that changes in calcium levels affect the EGF-induced nuclear translocation of MEKK2 and thereby its effect on the nuclear ERK5 activity.
Among men there was approximate proportionality, and thereby predictive effect, during the first 225 months, corresponding to 19 years.
