Sentence examples for and thereby activate from inspiring English sources

While several enzymes are capable of producing PA, the particular species of PA produced by PLD1 are preferentially bound by FRB domain and thereby activate mTOR kinase activity by displacing DEPTOR, an endogenous inhibitor of mTOR [ 41].

In this case, we found that phosphorylation of S184/T282 in the center domain of ZBTB16 by GSK3β may provide a signal to disrupt the inhibitory folding and thereby activate its auto-ubiquitination activity.

Constitutive activation of FGFR3 will probably cause constitutive activation of p38 MAPK and thereby activate the entire p38 MAPK signalling pathway.

A notable example is isochorismate synthase [18], in which a catalytic lysine is proposed to deprotonate and thereby activate a nucleophilic water molecule.

Bacteria release metabolites and toxins and thereby activate the immune system.

Dendritic cells present the antigens to naïve T-cells and thereby activate them.

This inactivates sororin and thereby activates the releasing activity that triggers cohesin's dissociation from chromosomes.

Trib3 inhibits Akt activity and thereby activates FOXO3a, which in turn binds to and activates the trib3 promoter.

In addition, active caspase-8 cleaves Bid to its active form tBid and thereby activates a certain amount of Bax/Bak but not enough for mitochondrial membrane permeabilisation.

The INSR is activated by insulin binding and after activation it phosphorylates and thereby activates insulin receptor substrate 1 (IRS1) which in turn activates the PI3-kinase and AKT signalling pathways.

Since proinflammatory NF-κB activation inhibits tuberous sclerosis complex 1 and thereby activates mTORC1 a potential link between APS and mTORC signaling may exist.