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The phrase "and there is a considerable difference" is correct and usable in written English.
You can use it when discussing or comparing two or more items, ideas, or situations to highlight a significant distinction between them.
Example: "While both methods are effective, there is a considerable difference in their efficiency and cost."
Alternatives: "and there is a significant disparity" or "and there is a notable distinction."
Exact(1)
Catheters used for adults are of different length, diameter and material than those used for children, and there is a considerable difference in the disease spectrum indicating CVC placement and use in children and adults.
Similar(59)
Now, it is clear that there is a considerable difference between symbol-rate sampling and oversampling.
Thus, there is a considerable difference between symbol-rate sampling and oversampling.
There is a considerable difference between the 24-hour recall and the dietary recall since birth.
"Indeed, objectively, we might say that such small doses had no effect.... Subjectively, however, there is a considerable difference".
Unsurprisingly, there is a considerable difference between the six countries.
But there's a considerable difference between a retail food establishment and a sit-down restaurant.
Thirdly, there was a considerable difference in incidence between the three cohorts (47%, 22% and 8%).
And that is a considerable difference.
That is a considerable difference.
There should be a considerable difference between these two rotating speeds.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com