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Eleven months after the irradiation, the sacral lesion showed slight progression with worsening of pain, and the second course of heavy ion irradiation (60.0 GyE/12 Fr) was administered.
Holland et al. (2010) from Pennsylvania State University, USA integrated architectural design courses using BIM as the technology platform, with their first course being integrated design studio and the second course being a two-semester capstone design course series.
And the second course of action is illegal under international law.
Then the 600 plates are cleared and taken to be washed and the second course goes out at 9 p.m., while there are more video tributes and toasts.
The first course was cyclophosphamide, doxorubicin and etoposide (CAE) and the second course was etoposide and cisplatin (CE) (see Materials and Methods for detailed description of dosing and toxicity) (Figure 9C).
The incidence of IRRs was markedly reduced with the second infusion and the second course.
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After the first course the sensitivity for assessment was 100%, with specificity of 85%, and accuracy 88% and after the second course the sensitivity was 83%, specificity 94% and an overall accuracy of 91%.
Lactone topotecan pharmacokinetic data were obtained in the first course of 16 patients and in the second course of 15 patients.
Total topotecan pharmacokinetic data were obtained in the first course of 32 patients and in the second course of 17 patients, respectively.
From 41 patients we obtained the QLQ-C30 questionnaires at baseline and after the second course, from 39 patients the OES18 questionnaires at these time points.
If the planned operation was abandoned in Protocols A and B, the second course of radiotherapy was started within 3 weeks.
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