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One is based on a two-dimensional readout of space coordinates, the other one is based on one space coordinate and the readout of the Time-of-Propagation (ToP).
The amplification and the readout of the small signal charges from the pixel sensor require highly integrated ASICs in which several thousand low-noise charge-sensitive amplifiers are densely interspersed with fast data-processing logic.
In addition, the number of donors included in each test, the time of incubation with the virus and the readout of the assay were all major variables amongst the different laboratories.
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Integrating the biosensor with microfluidics and confocal imaging enabled both long-term and high-speed manipulation of DEX environments and allowed the readout of the cell-by-cell response within embryonic Xenopus laevis AC explants.
Thus, histone methylation and deacetylation and DNA methylation have direct and indirect links that connect each of them to each other and to the readout of higher-order chromatin structures.
This is particularly difficult for some histone modifications such as methylation or acetylation of H3K9 and H3K27 which occur within an identical amino acid context (ARKS motif) and make the readout of the target peptide sequence outside of this central motif vital as well.
In addition to the photomultipliers the sphere contains all the electronics for production of the high voltage and for the readout of the signals of the photomultipliers.
IC 50 values are easier to determine than K i values and provide the readout of most primary biochemical assays (except single-point screening assays), which might at least in part rationalize greater target coverage and the IC 50-dependent increase in compound promiscuity across different families.
CP and MZ performed the readout of the MR examinations and were responsible for the descriptive statistics.
Among the main drawbacks are the limited physical area of SiPMs (increases the cost and the complexity of the readout of a camera) and their sensitivity to unwanted wavelengths.
The combinatorial nature of a histone code has led to the hypothesis that dynamic histone phosphorylation at S10 and S28 might affect the readout of stable methylation marks at the respective neighboring residues K9 and K27 [39].
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Justyna Jupowicz-Kozak
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