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Evaluation of this hypothesis will in the first instance involve carefully designed large population based observational studies to determine if an inverse relationship exists between the predisposition to ischemic vascular disease and the predisposition to solid cancer.
Recent research has begun to unravel the molecular basis for how cells read and write epigenetic codes and has also revealed a close association between epigenetic changes and the predisposition to, and development of, a wide range of human diseases [11].
Telomere length could offer a link between oxidative stress and the predisposition to epithelial cancers in T2DM [ 3].
In the present study, we re-evaluated the association between SNP rs705867 and the predisposition to AIS using data from a Chinese Han population.
In this way, a previously reported genetic association between IL-6 (-174 G/C) and the predisposition to IS in Italian patients [ 7] was confirmed among Bulgarian patients.
In fact, thanks to the tight correlation between specific HLA markers and the predisposition to certain autoimmune diseases, the HLA analysis has become a sensitive genetic tool to identify those individuals at high risk to develop these conditions [ 21].
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Human twin and family linkage studies as well as animal model studies have confirmed the importance of genetic factors in the individual variance in peak bone mass acquisition, BMD, bone geometry, and metabolism and thus the predisposition to osteoporosis and related fragility fractures.
The latter is an autosomal dominant hereditary neoplasia syndrome which is characterized by germline mutations of the vHL gene and by the predisposition to develop CNS or retinal HBL, renal cell carcinomas and cysts, pancreatic carcinomas and cysts, pheochromocytomas, and epididymal cystadenomas [ 32].
Anxiety as a trait, or anxiety level as a personal characteristic, is defined as a feeling of stress, nervousness, and discomfort which is experienced on a day to day basis (how the person usually feels) and means the predisposition to be anxious in different normal situations [ 14].
Studies have examined the possibility that SNPs in these genes may influence their expression and functional activity, and potentially alter the predisposition to cardiovascular disease [ 16- 18].
This also reflects the role of genetic and epigenetic modifications at important genes such as BRCA1 and BRCA2 in the predisposition to the disease [ 30].
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