This system has the potential to dramatically accelerate progress in cancer research, whether by modelling the genesis and progression of cancer in vitro and in vivo, screening for novel therapeutic targets, conducting functional genomics/epigenomics, or generating targeted cancer therapies.
Growing evidences show that epigenetic mechanisms play crucial roles in the genesis and progression of many physiopathological processes.
Given the role of mitochondria in oxygen consumption, metabolism and cell death regulation, alterations in mitochondrial function or dysregulation of cell death pathways contribute to the genesis and progression of cancer.
Thus, the combined use of etiologically realistic models and electrocorticography may improve our understanding of the genesis and progression of epilepsy, and facilitate discovery and translation of novel treatments.
Research on cancer epigenetics has flourished in the last decade as growing evidence points to the importance of understanding the mechanisms by which epigenetic changes regulate the genesis and progression of several pathologies, especially cancer.
To identify genetic events underlying the genesis and progression of multiple myeloma (MM), we conducted a high-resolution analysis of recurrent copy number alterations (CNAs) and expression profiles in a collection of MM cell lines and outcome-annotated clinical specimens.
Flow visualization within the human heart augments the percipience and experience of cardiologists and can assist in the understanding of the genesis and progression of cardiac abnormalities.
Aberrant stimulation of estrogen and androgen plays a central role in the genesis and progression of breast cancer and prostate cancer, respectively [41], [42].
RUNX3 has multiple functions and was at first reported to correlate with the genesis and progression of human gastric cancer as a tumor suppressor [2].
The role of ENT4 in the genesis and progression of DSRCT is unknown, but it may have a role in supporting tumorigenesis by providing growth and survival advantages to the tumor cells in adapting to a tumor microenvironment.
