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Ultimately, the existing recommendations were proven to capture most adults with IPD, and the extant data were not sufficient to support reducing the age of universal vaccination with PPV23 (7 ).
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Quantitative analysis and comparison with the extant data in rats showed both similarities and differences.
The current study (i) presents new data investigating this finding in a sample of 975 seven-year-old boys, and (ii) evaluates the extant data by conducting a meta-analysis of published findings.
Enforcing MIAME allowed many researchers to reexplore datasets from novel perspectives and " more and more research is now built on the analysis of data that were not collected by the researchers themselves, and many of the extant data have not been utilized to their full potential" [ 5].
Over the decade that followed, efforts were made to update this prosopographical database in terms of content and technology: Professor Michael Fuller migrated the data to a more usable format and Professor Peter Bol established collaborations with the Academia Sinica in Taiwan and Peking University to continue checking of the extant data and adding further individuals.
A graphic approach was used to identify age, period and cohort effects in the extant data of this study.
In this study, we integrate the extant data, and perform a whole genome resequencing of Japanese wild silkworm to obtain breakthrough results in silkworm mitochondrial (mt) population, and finally use these to deduce a more comprehensive phylogeny of the Bombycidae.
The modeling of the extant data constrains these variables, and the potential impact of the recent HESS detection on such parameters is addressed.
The extant data suggest that this relation is complex and not fully understood.
Because reduced CSF production could alter solute concentrations in CSF, we reviewed the extant data on CSF formation in the elderly and Alzheimer's patients.
Although many gaps exist in our knowledge on the mechanisms of imprinting on SDHD, balancing selection on SDHA and transcript mutations in SDHB, including their impact on SDH enzyme activity, the extant data on PGL suggest that these regulatory mechanisms might downregulate SDH function and facilitate early detection of and pre-adaptation to hypoxia (Figure 4).
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