The consequent transformations can be analyzed in terms of (neo- evolutionary mechaneo- evolutionary
We have previously proposed that the consumption of TGD can reduce the total amount of orally ingested calories via the consequent transformation of digestible substrate to indigestible fiber in the alimentary tract [ 2].
We suggested that the mechanism underlying the reduction in the total amount of orally ingested calories is the consequent transformation of digestible substrate to indigestible fiber in the alimentary tract.
An aberrant increase in the level of ROS may result in transient or permanent cellular alterations, such as irreversible oxidative damage on DNA, causing genomic instability and the consequent malignant transformation of the cells (8).
The Drosophila homologue of the CHD7 subfamily, kismet, was identified as a Trithorax gene and kismet mutants have reduced expression of homeotic genes and consequent transformations of body segments to more anterior structures (Daubresse et al., 1999).
Dietary manipulation of folate has been referred to as a 'double edge sword' because pharmacological depletion of folate by antifolate drugs prevents cancer cell proliferation but might induce genetic and epigenetic damage and consequent transformation in non-cancerous cells.
However, when both molecules are expressed, JunB prevents c-Jun DNA binding, transactivation and consequent transformation potential [ 55, 56].
Besides, the possible transformation and the consequent tumorigenesis of BMSCs themselves remains to be clarified.
Paramount among these transformations is the abbreviation of the tail and the consequent development of a pygostyle.
The authors suggested that these proteases are involved in malignant transformation via the proteolytic shedding of signalling molecules and the consequent transactivation of their receptors, such as the epithelial growth factor receptor and its ligands (Carl-McGrath et al, 2005).
Taken together, these data suggest that epigenetic alterations that occur early during malignant transformation might be a result from the modulation of miR-26, miR-29, miR-203, and the consequent effects on key genes involved in the epigenetic machinery.
