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Several hypotheses have been proposed, including imbalance in autonomic systems, increases in procoagulant activities, and systemic release of inflammatory mediators (Brook et al. 2004; Donaldson et al. 2001).
For instance, hemorrhagic shock and resuscitation and high PIP ventilation in rats interact to increase lung and systemic release of proinflammatory mediators (Figure 10).
In response to infection or injury, the liver re-prioritizes the synthesis and systemic release of many APPs.
Both humans and rodents exposed to PM develop pulmonary inflammation characterized by bronchoalveolar lavage (BAL) fluid pleocytosis accompanied by the local and systemic release of cytokines.
The liver orchestrates a host defense response by altering (re-prioritizing) the synthesis and systemic release of "acute phase proteins" (APPs, such as fetuin-A, also termed the alpha-2-HS-glycoprotein for the human homologue) [25].
CB2R activation reduces leukocyte activation and systemic release of inflammatory mediators in acute experimental sepsis.
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The initial phase of sepsis is thought in large part to be result of a 'cytokine storm' caused by the activation of innate and adaptive immune cells and the systemic release of pro-inflammatory mediators [ 2, 3].
Persistent local and systemic elevation of inflammatory cytokines promotes lipolysis, and the systemic release of free fatty acids contributes to the dyslipidemia seen in RA.
AKI in turn results in decreased cytokine clearance and increased systemic release of inflammatory markers, resulting in increased alveolar fluid and a pulmonary inflammatory reaction, even in previously healthy lung [ 103].
Conclusion: In patients presenting with nonshockable cardiac rhythm after OHCA, CsA administration prevented both CA induced lymphopenia and early systemic release of IL-10.
Given these results, we suspect that the symptoms of indolent mastocytosis are mostly unrelated to mast cell proliferation or infiltration; rather, it appears that the symptoms are the result of mast cell activation and the systemic release of mediators.
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